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Analyzing the effects on gene expression and DNA methylation that are shared between smoking and aging, the researchers noted that in people who quit smoking, non-reversible DNA methylation sites in the lung were enriched in DNA methylation sites that are associated with aging signatures, but this wasnt the case for reversible and partially reversible sites suggesting that the smoking effects that affect DNA methylation in common to aging are more persistent in time. This was not the case for gene expression changes

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Park HR, O'Sullivan M, Vallarino J, Shumyatcher M, Himes BE, Park JA, et al

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In challenging anti-smoking rules, the industry has drawn on global treaties, such as the 1994 pact known as TRIPS (the Agreement on Trade Related Aspects of International Property Rights), that include broad protections for intellectual property and foreign investment

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